Epidemiology of MS in Russia, a historical review

Background: This review summarizes several epidemiological studies of multiple sclerosis (MS) in Russia. Methods: The Authors selected the most well-organized population-based studies of MS prevalence and incidence in the huge territory of Russia. These studies were mostly published in Russian language and were unknown to international readers. Results: In the majority of Russian territories MS prevalence ranged from 30 to 70 cases per 100,000 population inhabitants. At most places where the epidemiology of MS had been assessed more than once, an increase in prevalence has been reported over time. Incidence showed fluctuations with an increase in Eastern parts of the country. This increased prevalence despite a relatively stable incidence in the European part of the country may reflect the increased survival of the MS population. Conclusions: Russia as a whole can be considered at medium risk for MS. Significant increase of prevalence rates have been recently reported, especially in Siberia and in the Far East regions of the country.